Anastrozole is a powerful Aromatase Inhibitor (AI) that was developed in 1995 by Zenaca Pharmaceuticals under the brand name Arimidex for the purpose of fighting breast cancer. Since its inception, Anastrozole has been one of the leading anti-estrogenic medications on the market. The compound has proven far more effective in breast cancer treatment plans than Tamoxifen Citrate (Nolvadex), although both compounds are regularly used.
Regardless of the purpose of use or the Anastrozole doses in question, the general purpose of use is the same, to suppress estrogen. This AI has been shown to have the ability to suppress serum estrogen levels in the body by more than 70%, which can be beneficial for many different reasons. For the breast cancer patient estrogen is the enemy as the cancer feeds on the hormone, and as Anastrozole reduces serum levels it aids in starving the cancer out. For breast cancer treatment standard Anastrozole doses will be 1mg per day until the cancer subsides. Once the cancer is in remission the Selective Estrogen Receptor Modulator Tamoxifen Citrate (Nolvadex) is often used to keep it in remission.
Many anabolic steroids, specifically those that aromatize, have the ability to promote estrogenic related side effects such as excess water retention and gynecomastia. This is due to the testosterone hormone aromatizing, which refers to the conversion of testosterone to estrogen. While we do need estrogen for a well functioning body, too much can be problematic. Supplementing with an AI can greatly reduce the risk of such effects; in fact, in most men it will eliminate them. For the anabolic steroid user standard Anastrozole doses will normally be 0.25-0.5mg every other day. Some may find 0.5mg two times per week to be sufficient. Dosing levels in this range will be enough to protect most men from gynecomastia as well as excess water retention that can occur due to the use of aromatizing steroids.
We're now left with the TRT patient, and he will be supplementing with Anastrozole for the same reason as the anabolic steroid user, to combat possible estrogenic related side effects. Standard Anastrozole doses for the TRT patient will normally be 0.25-0.5mg two times per week. Some may need 1mg two times per week but this can only be determined as time goes by. Further, some men may not need any Anastrozole at all if their estrogen levels do not increase too much. The majority of men will need an AI but there are those who do not aromatize testosterone heavily and will not require one on a TRT dose of testosterone. If you use an AI while already possessing proper estrogen levels, the low level state you will create will become excessively problematic. Severe low levels of estrogen in such cases can lead to erectile dysfunction, loss of libido, loss of energy, lack of mental clarity and joint pain, all of which are areas you are trying to correct due to a low testosterone condition. This is something well trained TRT physicians understand when dealing with low testosterone, and that is the importance of a proper balance between testosterone and estrogen.